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The microRNA-183 cluster: the family that plays together stays together

Shweta Dambal1, Mit Shah1, Brittany Mihelich1

  • 1Department of Pathology, University of Illinois at Chicago, 840 S. Wood Street, Room 130 CSN, MC 847, Chicago, IL 60612, USA.

Nucleic Acids Research
|July 15, 2015
PubMed

Insights

The microRNA-183 cluster (miRs-183, -96, -182) plays a crucial role in sensory organ development. Dysregulation of this microRNA family is linked to various diseases, including cancer and neurological disorders.

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • The microRNA (miR)-183 cluster contains miRs-183, -96, and -182, which share sequence homology.
  • Despite sequence similarity, subtle differences in seed sequences lead to overlapping and distinct mRNA targets, often within the same cellular pathways.

Purpose of the Study:

  • To review the conservation of the miR-183 cluster across evolution.
  • To elucidate the functional roles of the miR-183 family in normal development and disease.
  • To describe the regulation of cellular pathways by coordinated expression of these microRNAs.

Main Methods:

  • Literature review and synthesis of existing research on the miR-183 cluster.
  • Comparative analysis of miR-183 family conservation and function.
  • Discussion of regulatory mechanisms and pathway involvement.

Main Results:

  • The miR-183 family is essential for sensory organ maturation.
  • High expression of the miR-183 family is observed in non-sensory diseases like cancer and neurological disorders.
  • Coordinated expression of these microRNAs regulates vital cellular pathways.

Conclusions:

  • The genomic organization and conserved nature of the miR-183 family suggest significant evolutionary importance.
  • Understanding the miR-183 cluster's function in development and disease offers insights into therapeutic strategies.

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