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Related Experiment Video

Updated: Apr 7, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Defining medication adherence in individual patients.

Alan Morrison¹, Melissa E Stauffer¹, Anna S Kaufman¹

¹ScribCo, Effort, PA, USA.

Patient Preference and Adherence

|July 15, 2015

Summary

Pharmacokinetic adherence, defined by serum drug levels within the therapeutic range, offers a more precise measure than arbitrary dose-taking thresholds. This approach reclassifies medication adherence for patients like those using adalimumab.

Keywords:

adalimumab drug administration schedule drug therapy/utilization patient compliance pharmacokinetic adherence pharmacokinetics

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Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

Area of Science:

Pharmacology
Pharmacokinetics
Biomedical Engineering

Background:

Traditional medication adherence assessment relies on arbitrary dose-proportion thresholds.
This study introduces pharmacokinetic adherence, defined by maintaining serum drug levels within the therapeutic range.

Purpose of the Study:

To evaluate a novel definition of pharmacokinetic adherence for adalimumab.
To compare pharmacokinetic adherence with traditional adherence measures in psoriasis patients.

Main Methods:

Utilized pharmacokinetic modeling to calculate serum drug levels.
Employed medication event monitoring system data from seven psoriasis patients on adalimumab.
Compared calculated daily serum concentrations against a known therapeutic threshold.

Main Results:

No patients adhered to the precise 14-day adalimumab dosing interval.
Three patients were pharmacokinetically adherent, maintaining serum levels above the therapeutic threshold.
Four patients were pharmacokinetically non-adherent, with serum levels falling below the threshold for 3.5%-71.3% of days.

Conclusions:

Pharmacokinetic adherence provides a more accurate classification of patient adherence.
Serum drug concentrations, not just dosing frequency, determine therapeutic efficacy.
This refined definition impacts understanding of treatment effectiveness for adalimumab and similar drugs.