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Updated: Apr 7, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
Neuroleptic Malignant Syndrome: A Case Aimed at Raising Clinical Awareness
Jad Al Danaf1, John Madara1, Caitlin Dietsche1
1Department of Internal Medicine, Thomas Jefferson University Hospital, 1025 Walnut Street, Jefferson College Building, Suite 805, Philadelphia, PA 19107, USA.
Abstract:
A 60-year-old man with a history of bipolar disorder on risperidone, bupropion, and escitalopram was admitted for community acquired streptococcal pneumonia. Four days later, he developed persistent hyperthermia, dysautonomia, rigidity, hyporeflexia, and marked elevation of serum creatine phosphokinase. He was diagnosed with neuroleptic malignant syndrome (NMS) and improved with dantrolene, bromocriptine, and supportive therapy. This case emphasizes the importance of considering a broad differential diagnosis for fever in the ICU, carefully reviewing the medication list for all patients, and considering NMS in patients with fever and rigidity.
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