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Updated: Apr 7, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
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Study on the behavioral changes of a post-stroke depression rat model.

Chunfang Wu1, Junhe Zhang2, Yong Chen1

  • 1Department of Neurology, Henan University Huaihe Hospital, Kaifeng, Henan 475000, P.R. China.

Experimental and Therapeutic Medicine
|July 15, 2015
PubMed
Summary

Post-stroke depression (PSD) in rats significantly impairs learning and memory. PSD rat models show more severe behavioral and cognitive deficits than stroke-only models.

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Animal Models

Background:

  • Post-stroke depression (PSD) is a common complication following stroke.
  • Understanding the cognitive and behavioral impact of PSD is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the effects of post-stroke depression (PSD) on learning and memory in a rat model.
  • To compare the behavioral and cognitive changes in rats with PSD to those with stroke only.

Main Methods:

  • Wistar rats were divided into normal, stroke, and PSD groups.
  • Behavioral changes were assessed using open-field, sucrose solution consumption, and forced swimming tests at 3 and 7 days post-modeling.

Main Results:

Keywords:
post-stroke depressionrat modelstroke

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  • Rats with stroke showed reduced sucrose consumption and activity.
  • Rats with PSD exhibited significantly lower sucrose consumption, reduced activity, and increased immobility time compared to normal and stroke groups.
  • PSD rats demonstrated significantly impaired learning and memory capacity.

    • Conclusions:

    • Post-stroke depression significantly alters behavior and reduces memory capacity in rats.
    • The cognitive and behavioral deficits in PSD rats are more pronounced than in stroke-only rats.