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Correlation of high-sensitivity C-reactive protein and carotid plaques with coronary artery disease in elderly
Yanhong Liang1, Yuanping Hou1, Hongyu Niu1
1Department of Geriatric Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China.
Insights
High-sensitivity C-reactive protein (hs-CRP) and carotid plaques correlate with coronary artery disease (CAD) severity. These markers may improve CAD risk prediction in elderly patients.
Area of Science:
- Cardiology
- Biomarkers
- Vascular Ultrasound
Background:
- Coronary artery disease (CAD) poses a significant health risk.
- Identifying reliable predictors of CAD severity is crucial for patient management.
- Inflammation and atherosclerosis markers warrant investigation for their role in CAD progression.
Purpose of the Study:
- To investigate the association between high-sensitivity C-reactive protein (hs-CRP) levels and carotid plaque characteristics with the severity of coronary artery disease (CAD).
- To assess the potential of hs-CRP and carotid plaque features as predictors of CAD extent.
Main Methods:
- Coronary angiography was performed on 140 angina patients.
- Carotid intima-media thickness (IMT) and plaque characteristics were assessed using Color Doppler ultrasound.
- Serum hs-CRP levels were measured and correlated with CAD severity (single-, double-, multi-vessel disease).
Main Results:
- Multi-vessel disease patients exhibited significantly higher CCA IMT compared to control and single-vessel disease groups.
- Serum hs-CRP levels were markedly elevated in the multi-vessel disease group.
- Both hs-CRP levels and carotid plaque characteristics showed a strong correlation with CAD severity.
Conclusions:
- hs-CRP levels and carotid plaque characteristics are closely linked to the severity of coronary artery disease.
- These markers may serve as valuable tools for enhancing the prediction of CAD severity, particularly in elderly populations.
Abstract:
The aim of this study was to explore the correlation of high-sensitivity C-reactive protein (hs-CRP) and carotid plaques with the severity of coronary artery disease (CAD). A total of 140 patients with angina who underwent coronary angiography were selected and divided into a single-vessel disease group (n=11), double-vessel disease group (n=18), multi-vessel disease group (n=71) and control group (n=40). Color Doppler ultrasound was applied to measure the intima-media thickness (IMT) of the common carotid artery (CCA) and carotid bifurcation, and to record the location and number of carotid plaques. The serum hs-CRP level was also determined. Compared with the control and single-vessel disease groups, the multi-vessel disease group showed significantly higher IMT of the CCA (P<0.05). The serum hs-CRP level was highest in the multi-vessel disease group (P<0.01). The hs-CRP level and carotid plaque characteristics were found to correlate closely with the severity of CAD. Therefore, they may be used to improve the prediction of CAD severity in elderly patients.
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