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Association between matrix metalloproteinase-2 and matrix metalloproteinase-9 polymorphisms and endometriosis: A

Lingli Xin1, Qingxiang Hou1, Q I Xiong2

  • 1Department of Obstetrics and Gynecology, Second Artillery General Hospital of Chinese PLA, Beijing 100088, P.R. China.

Biomedical Reports
|July 15, 2015
PubMed

Insights

This meta-analysis found no link between specific matrix metalloproteinase gene variations (MMP-2 and MMP-9) and endometriosis risk. Further research with larger sample sizes is needed to confirm these findings on genetic predisposition.

Area of Science:

  • Genetics
  • Reproductive Medicine
  • Molecular Biology

Background:

  • Matrix metalloproteinase-2 (MMP-2) and MMP-9 gene polymorphisms have been suggested as risk factors for endometriosis.
  • Previous studies on these genetic associations had small sample sizes, leading to inconclusive results.

Purpose of the Study:

  • To conduct a meta-analysis to determine the association between MMP-2 (-735C/T) and MMP-9 (-1562C/T) polymorphisms and endometriosis risk.
  • To pool data from available case-control studies to increase statistical power and clarify the genetic predisposition to endometriosis.

Main Methods:

  • A comprehensive literature search was performed across PubMed, Embase, Web of Science, and CNKI.
  • Included studies were case-control in design, focusing on MMP-2 and MMP-9 polymorphisms in relation to endometriosis.
  • Odds ratios with 95% confidence intervals were calculated using fixed- or random-effect models.

Main Results:

  • Six case-control studies with a total of 2,486 participants were included in the meta-analysis.
  • No significant association was found between the MMP-2 (-735C/T) polymorphism and endometriosis risk.
  • Similarly, no significant association was identified between the MMP-9 (-1562C/T) polymorphism and endometriosis risk, even after stratified analysis.

Conclusions:

  • The current meta-analysis indicates no association between MMP-2 (-735C/T) and MMP-9 (-1562C/T) polymorphisms and the risk of developing endometriosis.
  • Larger, well-designed studies are recommended to further investigate the potential role of these genetic variations in endometriosis.
Keywords:
MMP-2MMP-9endometriosismeta-analysispolymorphism

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