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The human gingival indeterminate cell revisited.

K Warfvinge1

  • 1Department of Medical Cell Research, University of Lund, Sweden.

Scandinavian Journal of Dental Research
|December 1, 1989
PubMed
Summary
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Electron microscopy reveals indeterminate cells in gingival epithelium are not distinct. Gingival Langerhans cells show fewer Birbeck granules and more formative granules than epidermal cells.

Area of Science:

  • Oral biology
  • Dermatology
  • Cell biology

Background:

  • The presence of indeterminate cells in human gingival epithelium has been debated.
  • Previous studies suggested indeterminate cells are a distinct cell type within this epithelium.

Purpose of the Study:

  • To clarify the nature of indeterminate cells in human keratinized gingiva using electron microscopy.
  • To compare gingival Langerhans cells with epidermal Langerhans cells.

Main Methods:

  • Electron microscopic examination of over 100 dendritic cells in human keratinized gingiva.
  • Comparative analysis of cellular structures, specifically Birbeck granules, between gingival and epidermal Langerhans cells.

Main Results:

  • Electron microscopy demonstrated that indeterminate cells are not a separate cell type in gingival epithelium.

Related Experiment Videos

  • Identified sources of error contributing to the misconception of numerous indeterminate cells.
  • Gingival Langerhans cells exhibited significantly fewer Birbeck granules compared to epidermal Langerhans cells.
  • Granules in formative stages were common in gingival cells but rare in epidermal cells.

    • Conclusions:

    • Indeterminate cells in human gingival epithelium are not a distinct cell type.
    • Gingival and epidermal Langerhans cells display unique ultrastructural differences, particularly in granule content and formation.