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Related Experiment Video

Updated: Apr 7, 2026

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Intraprostatic ethanol diffusion: comparison of two injection methods using ex vivo human prostates.

B J King1, T K Mann-Gow1, M Kida2

  • 1Department of Surgery, University of Vermont, Burlington, VT, USA.

Prostate Cancer and Prostatic Diseases
|July 15, 2015
PubMed
Summary

A microporous hollow fiber catheter (MiHFC) significantly improved ethanol distribution for BPH treatment in human prostates compared to standard needles. This novel delivery method reduced backflow and created larger lesions, offering a promising alternative for BPH therapy.

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Area of Science:

  • Urology
  • Biomedical Engineering
  • Surgical Innovation

Background:

  • Intraprostatic ethanol injection for benign prostatic hyperplasia (BPH) has shown variable outcomes in clinical trials.
  • Ethanol backflow along the needle tract is a key factor limiting treatment efficacy.
  • Convection-enhanced delivery (CED) has previously demonstrated potential to mitigate backflow and improve ethanol distribution in animal models.

Purpose of the Study:

  • To compare the ethanol distribution pattern between a microporous hollow fiber catheter (MiHFC) and a standard needle in human prostates.
  • To evaluate the feasibility of using freshly harvested human prostates for assessing intraprostatic injection techniques.

Main Methods:

  • Human prostates were harvested from organ donors immediately post-mortem.
  • Absolute ethanol was injected into one lobe using a standard 21-gauge needle and into the contralateral lobe using a MiHFC.
  • Prostates were fixed, sectioned, and stained for 3D reconstruction to determine lesion volume.

Main Results:

  • The MiHFC resulted in significantly larger ethanol-induced lesions (1.14±0.52 cm³) compared to the standard needle (0.28±0.10 cm³).
  • No ethanol backflow was observed when using the MiHFC.
  • The study demonstrated the successful use of freshly harvested human prostates for evaluating injection techniques.

Conclusions:

  • Freshly harvested human prostates are a viable model for evaluating intraprostatic injection treatments.
  • The MiHFC significantly enhances ethanol distribution and lesion size compared to standard needles.
  • MiHFC represents a promising delivery system for intraprostatic ethanol injection therapy for BPH.