Automated diagnosis of coronary artery diseased patients by heart rate variability analysis using linear and

Monappa Gundappa Poddar1, Vinod Kumar, Yash Paul Sharma

  • 1Indian Institute of Technology Roorkee, Electrical Engineering , Roorkee , India and.

Insights

This study evaluated Heart Rate Variability (HRV) analysis for diagnosing Coronary Artery Disease (CAD). The PCA-SVM classifier achieved high accuracy, differentiating normal subjects from CAD patients effectively.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Signal Processing

Background:

  • Coronary Artery Disease (CAD) poses significant health risks, including myocardial infarction and sudden cardiac death.
  • Accurate and early diagnosis of CAD is crucial for effective patient management and improved outcomes.
  • Heart Rate Variability (HRV) analysis offers a non-invasive method to assess autonomic nervous system function, potentially indicative of cardiac health.

Purpose of the Study:

  • To assess the diagnostic performance of linear and non-linear Heart Rate Variability (HRV) features for classifying Normal (NOR) subjects and Coronary Artery Disease (CAD) patients.
  • To develop and evaluate classification software modules utilizing these HRV-derived features.

Main Methods:

  • Electrocardiogram (ECG) data were recorded from 60 Normal (NOR) subjects and 64 Coronary Artery Disease (CAD) patients.
  • RR interval tachograms were generated, and features were computed using time-domain, frequency-domain, and non-linear HRV analysis methods.
  • Principal Component Analysis (PCA) was employed for feature dimension reduction, followed by classification using Probabilistic Neural Network, K-Nearest Neighbour, and Support Vector Machine (SVM) algorithms.

Main Results:

  • The Principal Component Analysis combined with Support Vector Machine (PCA-SVM) classifier demonstrated significant diagnostic capability.
  • The PCA-SVM classifier achieved an overall accuracy of 91.67%.
  • Specific class sensitivities were reported as 86.67% for Normal subjects and 96.67% for Coronary Artery Disease patients.

Conclusions:

  • The study successfully differentiated between Normal subjects and Coronary Artery Disease patients using HRV analysis.
  • The PCA-SVM classifier, utilizing features from linear and non-linear HRV methods, proved effective for CAD diagnosis.
  • These findings suggest the potential of advanced HRV analysis as a valuable tool in the non-invasive diagnosis of Coronary Artery Disease.

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