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Related Concept Videos

Plasticity00:58

Plasticity

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Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
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Neuroplasticity01:01

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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
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Long-term Potentiation01:35

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Graded Potential01:19

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Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
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Propagation of Action Potentials01:23

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The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
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Related Experiment Video

Updated: Apr 7, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
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Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

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A Developmental Switch for Hebbian Plasticity.

Marijn B Martens1, Tansu Celikel2, Paul H E Tiesinga1

  • 1Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neuroinformatics, Radboud University Nijmegen, Nijmegen, The Netherlands.

Plos Computational Biology
|July 15, 2015
PubMed
Summary
This summary is machine-generated.

A developmental switch from spontaneous to evoked vesicle exocytosis enables Hebbian plasticity, crucial for brain circuit formation and learning. This transition ensures proper synaptic development, with disruptions potentially leading to neurodevelopmental disorders.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Computational Neuroscience

Background:

  • Hebbian plasticity is fundamental for sensory circuit development and adult learning and memory.
  • Synaptic plasticity underlies the formation of functional neural circuits during development.

Purpose of the Study:

  • To model neurotransmitter release dynamics during early postnatal cortical development.
  • To investigate how a switch in vesicle exocytosis mode triggers Hebbian plasticity.
  • To understand the roles of spontaneous vesicle exocytosis (SVE) and evoked vesicle exocytosis (EVE) in synaptic development.

Main Methods:

  • Computational modeling of neurotransmitter release dynamics.
  • Analysis of vesicle exocytosis modes (SVE and EVE).
  • Investigating the developmental timing of Hebbian plasticity.

Main Results:

  • A developmentally regulated switch from SVE to EVE triggers associative (Hebbian) plasticity.
  • SVE plays a permissive role, while EVE has an instructive role in Hebbian plasticity.
  • The balance between SVE and EVE controls the rate of Hebbian plasticity and enables spike-timing dependent plasticity maturation.

Conclusions:

  • The SVE to EVE switch is critical for the timed onset and maturation of Hebbian plasticity.
  • Improper timing or balance of this switch can lead to brain network malformations and neurodevelopmental disorders.