Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combinatorial Gene Control02:33

Combinatorial Gene Control

10.0K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
10.0K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

66.0K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
66.0K
Gene Flow02:39

Gene Flow

39.0K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
39.0K
Coordination of Gene Expression Processes in Bacteria01:29

Coordination of Gene Expression Processes in Bacteria

999
The DNA replication, transcription, and translation processes are intricately coupled in bacteria, allowing efficient gene expression and rapid protein synthesis. While this physical and functional coordination is advantageous, it introduces challenges that bacteria overcome through specific regulatory mechanisms.Coupling of Replication, Transcription, and TranslationThe coupling of replication, transcription, and translation is a hallmark of bacterial gene expression. As the replisome unwinds...
999
Sequence Networks of Rotating Machines01:24

Sequence Networks of Rotating Machines

539
A Y-connected synchronous generator, grounded through a neutral impedance, is designed to produce balanced internal phase voltages with only positive-sequence components. The generator's sequence networks include a source voltage that is exclusively in the positive-sequence network. The sequence components of line-to-ground voltages at the generator terminals illustrate this configuration.
Zero-sequence current induces a voltage drop across the generator's neutral impedance and other...
539
Genetic Drift03:33

Genetic Drift

45.2K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
45.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term evolution of regulatory DNA sequences. Part 1: simulations on global, biophysically-realistic genotype-phenotype maps.

Current opinion in genetics & development·2026
Same author

Long-term evolution of regulatory DNA sequences. Part 2: theory and future challenges.

Current opinion in genetics & development·2026
Same author

Invariant non-equilibrium dynamics of transcriptional regulation optimize information flow.

ArXiv·2025
Same author

Token-driven totally asymmetric simple exclusion processes.

Physical review. E·2025
Same author

Learning reshapes the hippocampal representation hierarchy.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Information Processing in Biochemical Networks.

Annual review of biophysics·2025
Same journal

Tension on dsDNA bound to ssDNA-RecA filaments may play an important role in driving efficient and accurate homology recognition and strand exchange.

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Amplitude-phase coupling drives chimera states in globally coupled laser networks [Phys. Rev. E 91, 040901(R) (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Erratum: Shapes of sedimenting soft elastic capsules in a viscous fluid [Phys. Rev. E 92, 033003 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Erratum: Attenuation of excitation decay rate due to collective effect [Phys. Rev. E 90, 022142 (2014)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells [Phys. Rev. E 92, 052715 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Lattice Boltzmann approach for complex nonequilibrium flows [Phys. Rev. E 92, 043308 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
See all related articles

Related Experiment Video

Updated: Apr 7, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
14:06

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

47.1K

Optimizing information flow in small genetic networks. IV. Spatial coupling.

Thomas R Sokolowski1, Gašper Tkačik1

  • 1Institute of Science and Technology Austria, Am Campus 1, A-3400 Klosterneuburg, Austria.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|July 15, 2015
PubMed
Summary
This summary is machine-generated.

Cells coordinate through local information exchange, improving signal transmission despite gene regulatory noise. Spatial coupling enables a novel regulatory strategy for enhanced information processing.

More Related Videos

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.7K
A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.9K

Related Experiment Videos

Last Updated: Apr 7, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
14:06

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

47.1K
Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.7K
A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.9K

Area of Science:

  • Systems biology
  • Computational biology
  • Molecular systems biology

Background:

  • Cells typically respond to external signals independently via gene expression.
  • Cells also exhibit local information exchange and coordination.
  • The role of spatial coupling in mitigating gene regulatory noise is unclear.

Purpose of the Study:

  • To extend an information-theoretic framework for gene regulation to spatially extended systems.
  • To investigate the benefits of spatial coupling for signal transmission in the presence of gene regulatory noise.
  • To explore how spatial coupling influences regulatory strategies and gene activation functions.

Main Methods:

  • Developed an information-theoretic framework for spatially extended gene regulation.
  • Modeled a lattice of nuclei expressing a diffusible target gene in response to a transcriptional regulator concentration field.
  • Analyzed information transmission and regulatory strategies under varying input concentrations and diffusion levels.

Main Results:

  • Diffusive coupling significantly enhances information transmission, especially at low input concentrations.
  • Optimal gene activation functions are systematically altered by spatial coupling.
  • A distinct regulatory strategy emerges where cells respond in a near-steplike manner, averaged by diffusion.

Conclusions:

  • Spatial coupling is beneficial for conveying signals subject to gene regulatory noise.
  • This framework provides insights into emergent regulatory strategies in spatially organized cellular systems.
  • The model is broadly applicable to stochastic gene expression in various spatially coupled biological systems, including early embryonic development.