[Development of acute renal failure in crush syndrome and the methods of their complex treatment]

The author analyzes the many-year clinical experience gained in the treatment of 225 patients suffering from acute renal insufficiency resultant from the crush syndrome. He discusses the mechanism of the prolonged crush syndrome development, complicated with acute renal or hepatorenal insufficiency. Symptomatic conservative therapy is described in detail. Special attention is paid to the principles and methods of present-day active therapy (hemodialysis, hemoperfusion, hemofiltration, plasmapheresis, plasmadiasorption; lymphologic detoxication methods, i.e. drainage of the thoracic lymph flow, endolymphatic infusion of etiopathogenetic agents). The author emphasizes that the treatment may be effective only when a complex of methods for detoxication and impaired homeostasis correction is employed.