Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From photons and their detectors, ultra short and "longer" times to tiny and giant PETs, golden eyes, AI and surgical probes - Nuclear Medicine has it all.

Zeitschrift fur medizinische Physik·2026
Same author

Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

Neurology·2026
Same author

Neurotransmitter-Informed Connectome Approach to Language Impairment After Stroke.

Stroke·2026
Same author

Sex-specific analysis of early disease course and treatment in a German multiple sclerosis cohort.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Antisemitism as a Chronic Cardiometabolic, Endocrine, and Glutamatergic Stressor Requiring Psychometric Monitoring.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
Same author

Endothelial dysfunction and metabolic biomarkers in post-COVID-19 syndrome.

Scientific reports·2026

Related Experiment Video

Updated: Apr 7, 2026

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
10:35

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

12.9K

Simultaneous PET/MRI in stroke: a case series.

Peter Werner1, Dorothee Saur2, Vilia Zeisig1

  • 1Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|July 16, 2015
PubMed
Summary
This summary is machine-generated.

Magnetic resonance imaging (MRI) has limitations in guiding stroke thrombolysis. Simultaneous positron emission tomography (PET)/MRI may improve accuracy in identifying critical hypoperfusion for better patient selection.

More Related Videos

Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
06:45

Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

Published on: June 2, 2023

2.4K
PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
12:01

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

Published on: June 14, 2018

13.4K

Related Experiment Videos

Last Updated: Apr 7, 2026

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
10:35

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

12.9K
Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
06:45

Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

Published on: June 2, 2023

2.4K
PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
12:01

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

Published on: June 14, 2018

13.4K

Area of Science:

  • Neurology
  • Radiology
  • Nuclear Medicine

Background:

  • Systemic thrombolysis for stroke is time-sensitive, with a critical window often exceeding 4.5 hours post-onset.
  • Previous prospective studies using MRI-guided thrombolysis beyond this window failed to meet primary endpoints.
  • Limited accuracy of MRI in quantifying critical hypoperfusion was identified as a potential reason for these failures.

Observation:

  • This study reports the first simultaneous use of [(15)O]H2O-positron emission tomography (PET) and MRI in stroke patients and an ovine model.
  • Discrepancies were noted between the simultaneous PET and MRI measurements.
  • These observed discrepancies may explain the current limitations of MRI in assessing stroke severity.

Findings:

  • Simultaneous [(15)O]H2O-PET/MRI provides complementary information regarding cerebral blood flow and tissue perfusion.
  • MRI underestimated the extent of critical hypoperfusion compared to PET in certain cases.
  • PET/MRI demonstrated potential for more accurate assessment of ischemic penumbra.

Implications:

  • [(15)O]H2O-PET/MRI may overcome the limitations of MRI alone in identifying critically hypoperfused brain tissue.
  • This combined imaging approach could significantly improve patient stratification for thrombolysis therapy in stroke.
  • Future clinical trials may benefit from incorporating advanced imaging techniques like PET/MRI for optimized treatment selection and improved outcomes.