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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
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Calcium supplements: benefits and risks
I R Reid1,2, S M Bristow1, M J Bolland1
1Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Journal of Internal Medicine
|July 16, 2015
Summary
Calcium supplements are not necessary for bone health in older women, as dietary intake shows no link to bone loss. The risks of supplements outweigh potential benefits, including increased gastrointestinal issues and cardiovascular events.
Area of Science:
- Nutritional Science
- Gerontology
- Bone Metabolism
Background:
- Optimal dietary calcium intake remains debated, particularly concerning osteoporosis pathogenesis.
- Existing research shows limited correlation between calcium consumption and bone density or loss rates.
Purpose of the Study:
- To investigate the relationship between dietary calcium intake and bone loss in healthy older women.
- To evaluate the efficacy and safety of calcium supplements in osteoporosis prevention and treatment.
Main Methods:
- Re-analysis of data from the placebo group of the Auckland Calcium Study.
- Assessment of bone loss over five years in women with varying calcium intakes (400-1500 mg/day).
- Review of meta-analyses and recent studies on calcium supplement efficacy and adverse events.
Main Results:
- No significant relationship was found between dietary calcium intake and the rate of bone loss.
- Calcium supplements showed acute, short-term benefits on bone resorption and density but no cumulative effect.
- Fracture prevention efficacy remains unproven, with no clear benefit for hip fractures.
- Supplements increased gastrointestinal side effects, renal calculi, and myocardial infarction risk.
Conclusions:
- Calcium supplements are not indicated for routine use in osteoporosis prevention or treatment due to a negative risk-benefit profile.
- Dietary calcium intake within a wide range appears sufficient for maintaining bone health in healthy older women.
- Adverse effects associated with calcium supplements may negate any potential benefits in fracture prevention.
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