Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new index for collagen induced platelet aggregation.

E Kakishita1, M Higuchi, A Suehiro

  • 1Second Department of Internal Medicine, Hyogo College of Medicine, Japan.

Thrombosis Research
|November 1, 1989
PubMed
Summary

We introduce the "R" value, a novel index for optical platelet aggregation testing. This new measure reflects platelet sensitivity to collagen and may indicate a prethrombotic state, showing differences in occlusive arterial disease phases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Herpesvirus Infection in Patients Following Bone Marrow Transplantation: Influence of Viral Reactivation on Prognosis.

Hematology (Amsterdam, Netherlands)·2016
Same author

Similarity Between Multiple Sclerosis and Idiopathic Central Nervous System Dysfunction After Bone Marrow Transplantation.

Hematology (Amsterdam, Netherlands)·2016
Same author

Acute Colonic Graft-versus-host Disease and Ulcerative Colitis with Respect to Cytokines.

Hematology (Amsterdam, Netherlands)·2016
Same author

Evaluation of platelet function by kinetic analysis of platelet aggregation.

Platelets·2010
Same author

Clinical significance of circulating hepatocyte growth factor, a new risk marker of carotid atherosclerosis in patients with Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2006
Same author

Age related elevation of serum macrophage colony stimulating factor (M-CSF) level.

Archives of gerontology and geriatrics·2004

Area of Science:

  • Hematology
  • Biomedical Engineering
  • Clinical Pathology

Background:

  • Optical aggregometry is a standard method for assessing platelet function.
  • Platelet aggregation plays a crucial role in thrombosis and hemostasis.
  • Existing parameters may not sufficiently capture subtle changes in platelet behavior.

Purpose of the Study:

  • To introduce and validate a new index, the "R" value, for optical platelet aggregometry.
  • To assess the utility of the "R" value in reflecting platelet sensitivity to collagen.
  • To evaluate the "R" value's potential in identifying prethrombotic states.

Main Methods:

  • Development of the "R" value, defined as the rate of change in the half time for platelet aggregation (T1/2) with varying platelet concentrations.

Related Experiment Videos

  • Application of the "R" value in optical aggregometry.
  • Comparison of "R" values with traditional platelet aggregation parameters in patients with occlusive arterial disease.

    • Main Results:

    • The "R" value quantifies platelet sensitivity to collagen.
    • "R" values demonstrated significant differences between acute and chronic phases of occlusive arterial disease.
    • Traditional platelet aggregation parameters did not show significant changes in these phases.

    Conclusions:

    • The "R" value is a sensitive indicator of platelet aggregability and collagen sensitivity.
    • A decreased "R" value suggests platelet hyperfunction and a hypercoagulable, or prethrombotic, state.
    • The "R" value offers a novel approach to identifying prothrombotic conditions.