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The prognostic performance of the complement system in septic patients in emergency department: a cohort study
Xin Zhao1, Yun-Xia Chen1, Chun-Sheng Li1
1Emergency Department, Beijing Chao-Yang Hospital, Capital Medical University, Chaoyang District, Beijing 100020, China.
Aim:
To investigate the prognostic performance of complement components in septic patients, complement 3, membrane attack complex (MAC) and mannose-binding lectin were measured and compared among adult patients with sepsis, severe sepsis and septic shock, as well as between in-hospital nonsurvivors and survivors.
Methods:
The prognostic value of complement components was compared with mortality in emergency department sepsis (MEDS) score.
Results:
Median complement 3, MAC and mannose-binding lectin increased directly with the sepsis, severe sepsis and septic shock groups, and were significantly higher in nonsurvivors than in survivors.
Conclusion:
MEDS and MAC independently predicted in-hospital mortality. The prognostic performance of MAC was superior to MEDS as analyzed by receiver operating characteristic curve and area under the curve.
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