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N-terminal pro-C-type natriuretic peptide in serum associated with bone destruction in patients with multiple myeloma
Anne K Mylin1, Jens P Goetze2, Lene Heickendorff3
1Department of Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Aim:
To examine whether N-terminal proCNP concentrations in serum is associated with bone destruction in patients with multiple myeloma.
Materials & Methods:
N-terminal proCNP and biochemical bone markers were measured in 153 patients. Radiographic bone disease and skeletal-related events were evaluated at specific time-points.
Results:
N-terminal proCNP concentrations increased with age. High N-terminal proCNP concentrations were associated with high-risk disease and renal impairment. Renal function explained 22% of the variation. N-terminal proCNP concentrations correlated with serum bone ALP and serum PINP, but lacked association with bone resorption markers, radiographic bone disease and skeletal-related events.
Conclusion:
Serum N-terminal proCNP are associated with bone formation activity in patients with multiple myeloma, but should be interpreted with caution in patients with renal impairment.
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