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Role of Group 1 CD1-Restricted T Cells in Infectious Disease

Sarah Siddiqui1, Lavanya Visvabharathy1, Chyung-Ru Wang1

  • 1Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine , Chicago, IL , USA.

Frontiers in Immunology
|July 16, 2015
PubMed

The evolutionarily conserved CD1 family of antigen-presenting molecules presents lipid antigens rather than peptide antigens to T cells. CD1 molecules, unlike classical MHC molecules, display limited polymorphism, making CD1-restricted lipid antigens attractive vaccine targets that could be recognized in a genetically diverse human population. Group 1 CD1 (CD1a, CD1b, and CD1c)-restricted T cells have been implicated to play critical roles in a variety of autoimmune and infectious diseases. In this review, we summarize current knowledge and recent discoveries on the development of group 1 CD1-restricted T cells and their function in different infection models. In particular, we focus on (1) newly identified microbial and self-lipid antigens, (2) kinetics, phenotype, and unique properties of group 1 CD1-restricted T cells during infection, and (3) the similarities of group 1 CD1-restricted T cells to the closely related group 2 CD1-restricted T cells.

Keywords:
CD1Mycobacterium tuberculosisNKT cellsT cellsanimal modelsantigen presentation

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