Tremor and Klinefelter's Syndrome
Marcie L Rabin1, Shivam Om Mittal2, Bahman Jabbari3
1Atlantic Neuroscience Institute, Summit, NJ, USA.
Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|July 16, 2015
Summary
Tremor in Klinefelter
Area of Science:
- Neurology
- Genetics
Background:
- Klinefelter's syndrome (KS) is linked to tremor, but details on its characteristics and management are scarce.
- Limited case reports exist on tremor phenomenology and treatment in individuals with KS.
Purpose of the Study:
- To investigate the nature of tremor in patients diagnosed with Klinefelter's syndrome.
- To explore potential treatment strategies for tremor associated with KS.
Main Methods:
- Case report of a 17-year-old male with dystonic tremor managed with deep brain stimulation (DBS).
- Case report of a 57-year-old male presenting with resting tremor and dystonic features.
Main Results:
- The observed tremor in both cases exhibited dystonic characteristics.
- Successful tremor management was achieved using deep brain stimulation (DBS) in one patient.
Conclusions:
- Tremor associated with Klinefelter's syndrome may primarily be dystonic.
- Deep brain stimulation (DBS) shows promise as a treatment option for KS-associated tremor.
- Further research is needed to understand the neurobiological mechanisms and optimize treatments.
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