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Updated: Apr 7, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Central arterial characteristics of gout patients with chronic kidney diseases
Gulperi Celik1, Sema Yilmaz2, Levent Kebapcilar3
1Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Selcuk University, Konya, Turkey.
Insights
Gout patients with chronic kidney disease (CKD) exhibit significantly worse arterial stiffness compared to those without CKD. This highlights the impact of kidney function on vascular health in gout patients.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Rheumatology
Background:
- Gout is associated with cardiovascular complications.
- Chronic kidney disease (CKD) is a known risk factor for arterial stiffness.
- The interplay between gout, CKD, and vascular health requires further investigation.
Purpose of the Study:
- To examine the relationship between central blood pressure, arterial stiffness, and renal function in gout patients.
- To compare these parameters in gout patients with and without CKD.
Main Methods:
- The study included 48 gout patients and 32 controls.
- Vascular measurements, including central blood pressure and arterial stiffness, were performed using an arteriograph.
- Renal function parameters were also assessed.
Main Results:
- Gout patients exhibited higher 24-hour pulse pressure, central systolic and diastolic blood pressure, cardiac output, and peripheral resistance than controls.
- Gout patients with CKD showed significantly elevated 24-hour pulse pressure, augmentation index, and daytime/nighttime pulse pressure compared to gout patients without CKD.
Conclusions:
- Gout patients with CKD demonstrate more pronounced arterial stiffness than those without CKD.
- Further large-scale studies are warranted to elucidate the impact of CKD on arterial stiffness in gout patients.
Background:
The aim of this study was to investigate the relationship between central blood pressure, arterial stiffness parameters and renal function parameters in gout patients with chronic kidney disease (CKD) and without CKD.
Methods:
The study enrolled 48 gout patients and 32 control subjects. Central blood pressure, arterial stiffness parameters and renal function parameters in gout patients were investigated. The vascular measurements were performed with an arteriograph.
Results:
Of the gout patients, 40.1% had CKD. The 24-h pulse pressure (PP) (P < 0.001), central systolic blood pressure (SBP) (P < 0.001), central diastolic blood pressure (DBP) (P < 0.001), cardiac output (CO) (P < 0.001) and peripheral resistance (P = 0.004) were significantly higher in the all patients with gout compared to healthy control subjects. Moreover, when the gout patients with and without CKD were compared, the gout patients with CKD had higher 24-h PP (P = 0.009), 24-h augmentation index standardized to a heart rate of 75 beats per min (AIx@75) (P < 0.023), daytime PP (P = 0.001), daytime AIx@75 (P = 0.027), and nighttime PP (P = 0.035) than the gout patients without CKD.
Conclusions:
In our study, gout patients with CKD had worse and more emphasized evidence of arterial stiffness than gout patients without CKD. Further investigations with large sample sizes are needed to evaluate the effect of CKD on the arterial stiffness of gout patients.
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