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Related Concept Videos

Cholinergic Receptors: Muscarinic01:25

Cholinergic Receptors: Muscarinic

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The pharmacological actions of acetylcholine are elicited via its binding to two families of cholinergic receptors or cholinoceptors, namely, muscarinic and nicotinic receptors. Muscarinic receptors are G protein-coupled receptors and have five subtypes, M1–M5. All mAChR subtypes are activated by acetylcholine and blocked by the antagonist, atropine. 
The subtypes M1, M3, and M5 couple with the Gq subunit and activate the phospholipase C (PLC) activity, mobilizing intracellular Ca2+....
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Related Experiment Video

Updated: Apr 7, 2026

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice
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Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual

R W Gould, D Dencker1, M Grannan

  • 1Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen , DK-2100 Copenhangen, Denmark.

ACS Chemical Neuroscience
|July 16, 2015
PubMed
Summary

M1 muscarinic acetylcholine receptor (mAChR) potentiation may treat cognitive deficits in schizophrenia. M1 mAChR knockout mice showed impaired learning, while a specific M1 modulator enhanced cognition in wild-type mice.

Keywords:
BQCAM1 knockout miceM1 muscarinic acetylcholine receptorsPositive allosteric modulatorstop-down processingtouchscreen cognition

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Cognitive Science

Background:

  • The M1 muscarinic acetylcholine receptor (mAChR) is crucial for learning and memory.
  • Cognitive impairments in schizophrenia, particularly in top-down processing, are a significant unmet clinical need.
  • M1 mAChR represents a promising therapeutic target for these deficits.

Purpose of the Study:

  • To investigate the role of M1 mAChR in top-down processing using a touchscreen visual discrimination task.
  • To assess the impact of M1 mAChR knockout (M1 KO) on learning and acquisition.
  • To evaluate the efficacy of an M1 positive allosteric modulator (BQCA) in enhancing cognitive performance.

Main Methods:

  • Utilized a touchscreen visual pairwise discrimination task in mice.
  • Compared learning rates and acquisition in M1 KO mice versus wild-type (WT) mice.
  • Administered the M1 positive allosteric modulator BQCA daily to WT and M1 KO mice.

Main Results:

  • M1 KO mice exhibited slower learning rates and required more days to acquire the discrimination task.
  • BQCA administration enhanced the learning rate and acquisition in WT mice but not in M1 KO mice.
  • Performance was not impaired in M1 KO mice or affected by BQCA in tasks without a top-down processing component (equal salience stimuli).

Conclusions:

  • These findings demonstrate performance deficits in M1 KO mice and cognitive enhancement with M1 potentiation in WT mice using touchscreen cognitive tasks.
  • The results highlight the critical role of M1 mAChR in top-down processing.
  • M1 mAChR potentiation shows potential as a therapeutic strategy for cognitive symptoms in schizophrenia.