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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Nucleosome Remodeling02:54

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Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
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In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
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Chromatin Isolation by RNA Purification ChIRP
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Long non-coding RNA and chromatin remodeling.

Pei Han1,2, Ching-Pin Chang1,3,4

  • 1a Krannert Institute of Cardiology and Division of Cardiology ; Department of Medicine; Indiana University School of Medicine ; Indianapolis , IN USA.

RNA Biology
|July 16, 2015
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) regulate genome structure and gene expression by interacting with chromatin modifiers. These interactions reveal complex feedback loops controlling gene accessibility and cellular function.

Keywords:
RNA therapeuticschromatin modificationchromatin remodelinghuman diseaseslncRNA promoterlncRNA regulationlong non-coding RNA

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Area of Science:

  • Molecular Biology
  • Genomics
  • Epigenetics

Background:

  • Long noncoding RNAs (lncRNAs) are key regulators of cellular processes.
  • lncRNAs influence genome structure and gene expression.
  • Their interactions with chromatin are crucial for biological functions.

Purpose of the Study:

  • To review recent advances in lncRNA research.
  • To focus on the functional mechanisms of lncRNA-chromatin interactions.
  • To highlight the regulatory roles of lncRNAs in chromatin dynamics.

Main Methods:

  • Literature review of recent studies on lncRNAs and chromatin.
  • Analysis of lncRNA-protein interactions with chromatin modifiers.
  • Discussion of regulatory feedback circuits involving lncRNAs and chromatin remodelers.

Main Results:

  • lncRNAs directly interact with chromatin-modifying enzymes and nucleosome-remodeling factors.
  • These interactions modulate chromatin structure and gene accessibility.
  • lncRNA expression is influenced by chromatin remodelers, indicating regulatory feedback.

Conclusions:

  • lncRNA-chromatin interactions are fundamental to genome regulation.
  • Understanding these mechanisms provides insights into gene expression control.
  • Further research on lncRNA functions will advance epigenetics and molecular biology.