[Lipid peroxidation and transmembrane transport in patients with chronic pyelonephritis]

Lipid peroxidation (LPO) and transmembranous transportation were analysed in the red cells of 56 patients with chronic pyelonephritis with regard to the pathologic changes in the membranes. LPO registration was made on the basis of the levels of diene conjugates and Schiff's bases. The activity of enzymes of transmembranous transportation-calcium, magnesium, sodium/potassium pump--was studied. The levels of the LPO markers were found to be tending to an increase in the active stage of the disease and to a decrease in its remission. Though the initial control levels of the markers were not reached. In the active stage of the disease the levels of diene conjugates were 59.66 +/- 6.43 nmol (42.6 +/- 94 nmol/litre in the control) while in the remission they were 22.16 +/- 3.22 a. u. (14.80 +/- 1.06 in the control). The results obtained are indicative of the polymorphism of clinically manifest metabolic changes. In the patients with higher levels of Ca2-ATPase the disease ran more silent than in those in whom the enzymic functional activity were lower. Inadequate activity of enzyme transmembranous transportation revealed in some patients in the course of manifest inflammation was a direct reflection of the failure in the mechanism of adaptation and an evidence of the initially heterogeneous activity (individuality) the enzymes of transmembranous cation transportation. The revealed phenomena contributed to the clinical course of pyelonephritis in a particular person and with regard to pathogenetic mechanisms required an approach to the therapy on an individual basis.