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Updated: Apr 7, 2026
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A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
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Maternal group B Streptococcus-related stillbirth: a systematic review
C Nan1, Z Dangor2,3, C L Cutland2,3
1Cassandra Nan, Research Consultant, Maastricht, the Netherlands.
Summary
Group B Streptococcus (GBS) can cause up to 12.1% of stillbirths. Limited and inconsistent epidemiological data highlight the need for standardized definitions and further research on GBS stillbirth.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Epidemiology
Background:
- Limited epidemiological data exists on the association between maternal Group B Streptococcus (GBS) colonization and stillbirth.
- This data gap hinders the assessment of antenatal interventions for preventing GBS-related stillbirth.
Purpose of the Study:
- To systematically review existing literature on GBS-related stillbirth.
- To evaluate the incidence of GBS-related stillbirth by region up to March 2015.
Main Methods:
- A systematic literature review was conducted using multiple databases (PubMed/MEDLINE, EMBASE, LILACS, Cochrane Library).
- Search terms and definitions were based on CDC's Active Bacterial Core Surveillance (ABCs) criteria for GBS-related stillbirth and chorioamnionitis.
- Studies included original data on stillbirths (≥20 weeks gestation) with confirmed GBS via autopsy or culture from sterile sites.
Main Results:
- Seventeen studies reported GBS-related stillbirth rates from 0.04 to 0.9 per 1000 births.
- The proportion of stillbirths attributed to GBS ranged from 0% to 12.1%.
- Most data originated from before 2000 and from high-income countries.
Conclusions:
- Inconsistent reporting and sparse epidemiological evidence underscore the need for standardized stillbirth definitions and diagnostic methods.
- Standardization is crucial for effectively assessing antenatal interventions.
- Gaps in evidence include stillbirth timing, GBS serotypes, and global diversity.
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