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Related Concept Videos

Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
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A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
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Subcutaneous fat necrosis causing neonatal hypercalcaemia.

Emma Tuddenham1, Arun Kumar2, Anne Tarn1

  • 1Department of Clinical Biochemistry, South-West London Pathology Network, Croydon, UK.

BMJ Case Reports
|July 17, 2015
PubMed
Summary
This summary is machine-generated.

Severe hypercalcaemia in newborns, a rare condition, can cause serious health issues. Prompt recognition of subcutaneous fat necrosis of the newborn is crucial to prevent kidney damage.

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Area of Science:

  • Neonatal Medicine
  • Pediatric Endocrinology

Background:

  • Hypercalcaemia in neonates is uncommon but can lead to significant morbidity.
  • Severe hypercalcaemia may present with irritability, vomiting, and seizures.

Observation:

  • A case of a neonate girl with severe hypercalcaemia and nephrocalcinosis is presented.
  • The infant experienced subcutaneous fat necrosis of the newborn following a traumatic delivery.
  • Prolonged low-level elevation of C-reactive protein was noted.

Findings:

  • Subcutaneous fat necrosis of the newborn is a rare, often underdiagnosed condition.
  • This condition is frequently associated with elevated plasma calcium levels.
  • The neonate recovered well, though some nephrocalcinosis persisted.

Implications:

  • Early recognition and treatment of subcutaneous fat necrosis of the newborn are vital.
  • Minimizing kidney damage is a key treatment goal.
  • Appropriate diagnosis avoids unnecessary investigations and prolonged antibiotic use.