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Updated: Apr 7, 2026
Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
Published on: October 6, 2023
Assessing the Reliability of a Semiautomated Segmentation Algorithm for Quantifying Erosions in the
Michael A Tomizza1, Matthew A Jessome1, Joshua Barbosa1
1From the Department of Medical Sciences, Department of Medicine, and Faculty of Health Sciences, McMaster University; Department of Diagnostic Imaging, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.M.A. Tomizza, BSc, Department of Medical Sciences, McMaster University; M.A. Jessome, BHSc; J. Barbosa, BHSc, Faculty of Health Sciences, McMaster University; K.A. Beattie, PhD; W.G. Bensen, MD; R.S. Bobba, MD; A.A. Cividino, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; P.D. Emond, PhD; C. Gordon, PhD, St. Joseph's Healthcare Hamilton; L. Hart, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; G. Ioannidis, PhD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; M.X. Koh, BHSc, Faculty of Health Sciences, McMaster University; M. Larché, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton; R. Tavares, PhD; S. Tytus, MD, St. Joseph's Healthcare Hamilton; J.D. Adachi, MD, Department of Medicine, McMaster University, and St. Joseph's Healthcare Hamilton.
Objective:
Assess the reliability of early erosions in rheumatoid arthritis (EERA) software for quantifying erosive damage to the metacarpophalangeal joints of patients with rheumatoid arthritis (RA).
Methods:
One hundred magnetic resonance image sets from 68 patients with early referral RA were evaluated. Reliability was assessed using 95% limits of agreement and intraclass correlation coefficient (ICC) with 95% CI.
Results:
Limits of agreement linearly depended on erosion volume: 0.44× between readers and 0.19× within readers. Interrater ICC was 0.976 (95% CI 0.965-0.984) and intrarater ICC was 0.996 (95% CI 0.994-0.997).
Conclusion:
EERA is highly reproducible for quantifying erosions in patients with early RA.
