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Related Experiment Video

Updated: Apr 7, 2026

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
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Hyponatremia predicts mortality after stroke.

Roy L Soiza1,2, Kirsten Cumming2, Allan B Clark3

  • 1Department of Geriatric Medicine, Aberdeen Royal Infirmary, Aberdeen, Scotland, UK.

International Journal of Stroke : Official Journal of the International Stroke Society
|July 17, 2015
PubMed
Summary
This summary is machine-generated.

Hyponatremia, or low serum sodium, is common in stroke patients and linked to increased mortality, especially in those under 75 years old. This study highlights the importance of monitoring sodium levels post-stroke.

Keywords:
dysnatremiahyponatremiaoutcomesprognosissodiumstroke

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Area of Science:

  • Neurology
  • Internal Medicine
  • Clinical Chemistry

Background:

  • Hyponatremia (low serum sodium) is the most frequent electrolyte disturbance in clinical practice.
  • Adverse outcomes are associated with hyponatremia, yet its specific impact on stroke mortality remains under-investigated.

Purpose of the Study:

  • To examine the relationship between serum sodium levels upon admission and mortality risk at different intervals following a stroke.
  • To assess the independent association of hyponatremia and hypernatremia with stroke mortality.

Main Methods:

  • A consecutive series of 8540 acute stroke patients admitted between January 2003 and June 2013 were analyzed.
  • Mortality outcomes were tracked until December 2013.
  • Statistical models (odds ratios/hazards ratios) were used to evaluate mortality at 7 days, 8-30 days, 1 year, and overall follow-up, adjusting for multiple clinical and biochemical factors.

Main Results:

  • The prevalence of hyponatremia and hypernatremia upon admission was 13.8% and 3.3%, respectively.
  • Severe hyponatremia was independently associated with significantly higher mortality across all time points (e.g., OR 3.31 within one year).
  • Poorer outcomes were observed in younger hyponatremic patients (under 75 years).

Conclusions:

  • Hyponatremia is a frequent finding in patients admitted with acute stroke.
  • Admission hyponatremia is an independent predictor of increased mortality, particularly in patients younger than 75 years.