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Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent

Marisa H Miceli1, Carol A Kauffman2

  • 1Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Health System.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|July 17, 2015
PubMed

Insights

Isavuconazole is a new antifungal medication effective against various fungi, including invasive aspergillosis and mucormycosis. Clinical trials show it is as effective as voriconazole and well-tolerated with fewer drug interactions.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Isavuconazole is an extended-spectrum triazole antifungal agent.
  • It demonstrates activity against yeasts, molds, and dimorphic fungi.
  • Approved for invasive aspergillosis and mucormycosis treatment.

Purpose of the Study:

  • To evaluate the efficacy and safety of isavuconazole.
  • Compare isavuconazole with voriconazole for invasive aspergillosis.
  • Assess isavuconazole in invasive mucormycosis treatment.

Main Methods:

  • Randomized, double-blind clinical trial for invasive aspergillosis.
  • Open-label trial for invasive mucormycosis (primary and salvage therapy).
  • Pharmacokinetic and safety assessments in patients and volunteers.

Main Results:

  • Isavuconazole demonstrated non-inferior efficacy to voriconazole in invasive aspergillosis.
  • Efficacy in invasive mucormycosis was similar to amphotericin B and posaconazole.
  • Isavuconazole was well-tolerated with a favorable safety profile and fewer drug-drug interactions.

Conclusions:

  • Isavuconazole is an effective and well-tolerated treatment option for invasive aspergillosis and mucormycosis.
  • Its predictable pharmacokinetics and favorable drug interaction profile are advantageous.
  • Further clinical experience will define its role in treating invasive fungal infections.
Keywords:
aspergillosisisavuconazoleisavuconazonium sulfatemucormycosistriazoles

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