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A Indole-Trizole-Rhodamine Triad as Ratiometric Fluorescent Probe for Nanomolar-Concentration Level Hg(2+) Sensing
Heng Liu1,2, Hui Ding1, Lili Zhu3
1School of Chemistry & Chemical Engineering, University of Chinese Academy of Sciences (UCAS), Beijing, 100049, China.
Abstract:
A new type of ratiometric fluorescent probe capable of detecting Hg(2+) ions at nanomolar-concentration level with high selectivity was developed based on an indole-trizole-rhodamine triad and its practicability for intracellular Hg(2+) sensing was verified. The as-prepared fluorescent probe is capable of detecting Hg(2+) over other competing metal ions including Ag(+) with high selectivity. The synergistic effect of Hg(2+)-assisted conversion of the nonfluorescent ring-closed rhodamine moiety to the highly fluorescent ring-open form as well as the fluorescence signal amplification originating from the Förster resonance energy transfer (FRET) from indole-trizole conjugate to rhodamine moiety contributed to a detection limit of 11 nM of the probe for Hg(2+) sensing.
