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Updated: Apr 7, 2026
Performing In Vivo and Ex Vivo Electrical Impedance Myography in Rodents
Published on: June 8, 2022
Electrical impedance myography discriminates congenital muscular dystrophy from controls
Daniel P Schwartz1, Jahannaz Dastgir2,3, Anam Salman1
1Electromyography Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, CRC Room 7SW-5680, 10 Center Drive MSC 1404, Bethesda, Maryland, 20892, USA.
Introduction:
Electrical impedance myography (EIM) is an emerging non-invasive, highly reproducible electrophysiological technique that objectively characterizes muscle structure and composition by measuring bioimpedance. We assessed the ability of EIM ability to discriminate 2 forms of congenital muscular dystrophy (CMD), laminin α2 (LAMA2)-deficient CMD and collagen VI-deficient (COL6) CMD, from a group of healthy children. We also investigated correlations between subcutaneous fat thickness and EIM parameters.
Methods:
Twenty-eight children with LAMA2 CMD (n = 12) or COL6 (n = 16) CMD and 18 normal children underwent EIM testing.
Results:
The EIM 50-kHz phase was decreased in LAMA2 and COL6 CMD when compared with controls (P < 0.001). Reactance, however, was decreased in COL6 but not LAMA2 CMD compared with controls (P < 0.001).
Conclusions:
Our findings suggest that EIM may be useful in discriminating CMD from controls and may serve as a useful biomarker to follow disease progression in clinical trials.
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