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Updated: Apr 7, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Glomerulomegaly in lupus nephritis: a prognostic marker for renal outcomes

Hironari Hanaoka1, Masataka Kuwana1,2, Tsutomu Takeuchi1

  • 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

International Journal of Rheumatic Diseases
|July 17, 2015
PubMed

Insights

Glomerulomegaly, or enlarged glomeruli, may predict worse kidney outcomes in lupus nephritis (LN). Early detection of enlarged glomeruli in lupus nephritis can indicate a poorer renal prognosis.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Glomerulomegaly, the abnormal enlargement of glomeruli, is linked to progressive chronic kidney disease (CKD).
  • Its role in lupus nephritis (LN) prognosis has been understudied.
  • This study investigates glomerulomegaly as a prognostic factor in LN renal pathology.

Purpose of the Study:

  • To assess glomerulomegaly as a prognostic factor for renal pathology in lupus nephritis.
  • To identify baseline predictors of complete renal response (CR) at 3 years.
  • To evaluate long-term renal outcomes up to 10 years.

Main Methods:

  • Retrospective analysis of patients with class III or IV LN.
  • Division into groups based on complete renal response (CR) at 3 years.
  • Comparison of baseline clinical and pathological findings, with up to 10-year follow-up.

Main Results:

  • Patients without CR showed longer disease duration and higher proteinuria at baseline.
  • A higher proportion of patients without CR exhibited enlarged glomeruli (segmentally or minimally affected).
  • Patients with enlarged glomeruli had a worse 10-year CR rate; glomerular area correlated with disease duration.

Conclusions:

  • Enlarged glomeruli at LN diagnosis may predict poorer renal prognosis.
  • Mechanical glomerular injury could impact clinical outcomes in lupus nephritis.
Abstract

Keywords:
glomerulomegalylupus nephritissystemic lupus erythematosus

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