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Updated: Apr 7, 2026

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
Published on: November 8, 2024
Pictorial prescribing reduces fentanyl drug administration errors: a simulated controlled study
Stephen W Booth1, Maria Gloag2, Sara Kinna2
1Division of Anaesthesia, University of Cambridge, Cambridge, UK.
Pictorial prescribing significantly reduced medication errors in choosing fentanyl preparations among nurses. This strategy improves understanding and may prevent errors with non-interchangeable drug products.
Area of Science:
- Pharmacology
- Patient Safety
- Medical Education
Background:
- Transmucosal fentanyl formulations (intranasal, sublingual, buccal, lozenges) are used for cancer pain but are not interchangeable.
- Variations in transmucosal fentanyl products can lead to medication errors.
Purpose of the Study:
- To compare medication errors using handwritten drug charts versus pictorial self-adhesive labels for fentanyl prescriptions.
- To assess the impact of pictorial labels on nurses' understanding of fentanyl preparation and dosing.
Main Methods:
- 54 nurses evaluated simulated handwritten and pictorial prescription charts.
- Nurses identified intended fentanyl preparations and doses from available product options.
- Medication errors and prescription clarity were measured using Likert scales.
Main Results:
- Pictorial labels significantly reduced errors in selecting the correct fentanyl preparation (20 vs. 6 errors).
- No significant difference was found in dose errors between the two chart types.
- Pictorial labels substantially improved nurses' understanding of preparation, dose, and maximum dosing intervals.
Conclusions:
- Pictorial prescribing is a promising strategy to decrease medication errors related to fentanyl preparation selection.
- The use of pictorial prescribing may be beneficial for other drugs with non-interchangeable formulations.
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