Related Experiment Video
Updated: Apr 7, 2026
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
MicroRNAs Determining Inflammation as Novel Biomarkers and Potential Therapeutic Targets
Athanassios Kotsinas, Fragkiska Sigala, Spiros D Garbis
1Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, Athens, Greece; and Cancer and Clinical Experimental Science Units, Faculty of Medicine, Institute for Life Sciences, Center for Proteome Research, University of Southampton, Southampton, UK. vgorg@med.uoa.gr.
Insights
Micro-RNAs (miRNAs) are key players in cardiovascular diseases (CVDs), influencing both disease development and progression. These microRNAs show potential as biomarkers and therapeutic targets for CVDs.
Area of Science:
- Biomedical research
- Molecular biology
- Cardiology
Background:
- Cardiovascular diseases (CVDs) are a leading global cause of mortality.
- CVDs include atherosclerosis and aneurysm formation, driven by complex pathophysiologic mechanisms.
- Micro-RNAs (miRNAs) are increasingly recognized for their critical roles in CVD initiation and progression.
Purpose of the Study:
- To review the involvement of miRNAs in cardiovascular diseases.
- To highlight the regulatory role of miRNAs in the inflammatory processes underlying CVDs.
- To discuss the potential of miRNAs as biomarkers and therapeutic targets for CVDs.
Main Methods:
- Literature review of existing data on miRNAs and CVDs.
- Analysis of studies focusing on miRNA regulation of inflammation in cardiovascular contexts.
- Synthesis of information regarding miRNA biomarkers and therapeutic strategies.
Main Results:
- Certain miRNAs promote CVD development, while others exert protective effects.
- miRNAs are implicated as significant regulators of inflammation, a key component in CVD pathogenesis.
- miRNAs demonstrate potential as diagnostic biomarkers for various CVDs.
Conclusions:
- Micro-RNAs play a dual role in cardiovascular diseases, acting as both promoters and protectors.
- Targeting miRNAs offers a promising avenue for novel therapeutic interventions in CVD treatment.
- Understanding miRNA-mediated inflammation is crucial for advancing CVD research and clinical practice.
Abstract:
Cardiovascular diseases (CVDs) have become a predominant cause of death worldwide. Although CVDs encompass a variety of pathological conditions that affect the heart and blood vasculature, they can be classified into two major groups according to their basic pathophysiologic mechanisms, namely atherosclerosis and aneurysm formation. Increasing evidence implicates micro-RNAs (miRNAs or miRs) as vital factors both in the initiation and progression processes of CVDs. Some miRs have a promoting role in CVD development, while others have a protective role. Today, miRs have been shown to be potential biomarkers for several types of CVDs, while strategies targeting miRs are under consideration as potential tools for exploitation in therapeutic approaches for CVD treatments. In this review, we present the available data on the involvement of miRs in CVDs, focusing on their role as regulators of the inflammatory process as an initiating and driving component of CVDs.
More Related Videos
10:37Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
13:36Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
Published on: July 23, 2012
Related Concept Videos
01:22MicroRNAs
01:22MicroRNAs
01:22MicroRNAs
02:30siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...