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Effect of Lycopene on Serum Nitrite-Nitrate Levels in Diabetic Rats
Sevım Ç Yegın1, Fatmagül Yur2, S Çetın2
1Giresun University, Health Service Vocational School of Higher Education, Giresun, Turkey.
Indian Journal of Pharmaceutical Sciences
|July 17, 2015
Summary
Diabetic rats showed increased serum nitrate-nitrite levels due to oxidative stress. Lycopene, an antioxidant, also increased these levels, suggesting a complex interaction in diabetes.
Area of Science:
- Biochemistry
- Endocrinology
- Nutritional Science
Background:
- Diabetes mellitus is associated with oxidative stress.
- Nitrate and nitrite levels are indicators of nitric oxide metabolism.
- Lycopene is a potent antioxidant with potential therapeutic benefits.
Purpose of the Study:
- To investigate the effect of lycopene on serum nitrate-nitrite levels in diabetic rats.
- To explore the relationship between oxidative stress, diabetes, and nitric oxide metabolism.
- To assess lycopene's impact on nitrate and nitrite concentrations in a diabetic model.
Main Methods:
- Twenty-eight Wistar rats were divided into four groups: control, diabetes, diabetes-lycopene, and lycopene.
- Serum nitrate and nitrite concentrations were measured.
- The ratio of nitrite to nitrate was determined to infer nitric oxide radical formation.
Main Results:
- Serum nitrate and nitrite levels were significantly elevated in diabetic rats compared to controls.
- Lycopene administration, both in diabetic and non-diabetic rats, also resulted in increased nitrate and nitrite levels.
- The increase in nitrate levels was particularly significant in the diabetes and lycopene groups compared to the diabetes-lycopene and control groups.
Conclusions:
- Oxidative stress in diabetes leads to increased serum nitrate and nitrite levels.
- Lycopene, despite its antioxidant properties, also elevated nitrate and nitrite levels in this study.
- Further research is needed to understand the stability and recovery of nitrate and nitrite in biological samples and the precise role of lycopene in nitric oxide metabolism during diabetes.
