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[Multi-infarct dementia in the very elderly].

R S Jazemirskaja¹

¹Forschungsinstitut für Endokrinologie und Gerontologie, Akademie der Medizinischen Wissenschaften der VR Bulgarien.

Zeitschrift Fur Alternsforschung

|November 1, 1989

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Multi-infarction dementia in long-lived individuals shows three clinical variants and a generally unfavorable course, particularly pronounced in physically active patients. The study observed patients until death, noting a terminal vegetative state.

Area of Science:

Neurology
Gerontology
Pathology

Context:

Study focuses on multi-infarction dementia (MID) in a cohort of long-lived individuals.
The research specifically examines elderly patients from Sofia, with an average age of 92.4 years.
Patients were followed throughout their lifespan until mortality.

Purpose:

To investigate the clinical characteristics and course of multi-infarction dementia in the very old.
To identify distinct clinical variants of MID in a long-lived population.
To assess the impact of physical activity on the manifestation of MID in advanced age.

Summary:

The study identified three clinical variants of multi-infarction dementia: lacunar, amnestic, and pseudoparalytic.
Physically active long-lived patients exhibited more pronounced clinical peculiarities of the disease.

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In the terminal stage, patients often reached a vegetative state, indicating a severe prognosis.

Impact:

Highlights the specific clinical presentation and progression of MID in the elderly.
Suggests that physical activity may influence the symptomatic expression of MID.
Underscores the generally unfavorable prognosis of multi-infarction dementia in long-lived individuals.