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[Multi-infarct dementia in the very elderly].

R S Jazemirskaja1

  • 1Forschungsinstitut für Endokrinologie und Gerontologie, Akademie der Medizinischen Wissenschaften der VR Bulgarien.

Zeitschrift Fur Alternsforschung
|November 1, 1989
PubMed
Summary

Multi-infarction dementia in long-lived individuals shows three clinical variants and a generally unfavorable course, particularly pronounced in physically active patients. The study observed patients until death, noting a terminal vegetative state.

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Area of Science:

  • Neurology
  • Gerontology
  • Pathology

Context:

  • Study focuses on multi-infarction dementia (MID) in a cohort of long-lived individuals.
  • The research specifically examines elderly patients from Sofia, with an average age of 92.4 years.
  • Patients were followed throughout their lifespan until mortality.

Purpose:

  • To investigate the clinical characteristics and course of multi-infarction dementia in the very old.
  • To identify distinct clinical variants of MID in a long-lived population.
  • To assess the impact of physical activity on the manifestation of MID in advanced age.

Summary:

  • The study identified three clinical variants of multi-infarction dementia: lacunar, amnestic, and pseudoparalytic.
  • Physically active long-lived patients exhibited more pronounced clinical peculiarities of the disease.
  • In the terminal stage, patients often reached a vegetative state, indicating a severe prognosis.

Impact:

  • Highlights the specific clinical presentation and progression of MID in the elderly.
  • Suggests that physical activity may influence the symptomatic expression of MID.
  • Underscores the generally unfavorable prognosis of multi-infarction dementia in long-lived individuals.

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