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[A rapid test for detecting Clostridium difficile].

W Karsch, E Strelau, E Fischer

    Zeitschrift Fur Die Gesamte Hygiene Und Ihre Grenzgebiete
    |October 1, 1989
    PubMed
    Summary
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    The coagglutination test (coa-test) offers a rapid and simple method for detecting Clostridium difficile. While highly accurate for bacterial cultures, further confirmation is needed for stool specimens.

    Area of Science:

    • Microbiology
    • Immunology

    Context:

    • Clostridium difficile is a significant cause of infectious diarrhea.
    • Accurate and rapid diagnostic methods are crucial for timely treatment and infection control.

    Purpose:

    • To evaluate the efficacy of a coagglutination (coa-test) assay for the detection of Clostridium difficile.

    Summary:

    • The coa-test, utilizing anti-Clostridium difficile serum-coated Staphylococcus aureus cells, was compared against bacterial culture for identifying C. difficile in bacterial cultures and stool specimens.
    • In bacterial cultures (n=275), the coa-test demonstrated high sensitivity (98.9%) and specificity (90.2%).
    • In stool specimens (n=206), sensitivity was 75.0% and specificity was 75.8%.
    • The test showed a high negative predictive value in both settings (97.6% and 97.3%).

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  • Cross-reactivity was observed with Clostridium bifermentans and Clostridium sordelli.

    • Impact:

    • The coa-test serves as a potentially useful, rapid screening tool for Clostridium difficile detection.
    • Positive coa-test results require confirmation by bacterial culture.
    • Further validation may be needed for stool specimen analysis due to lower specificity.