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Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions
Published on: September 10, 2021
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Large-scale disaster and gastrointestinal diseases.
Keiichi Tominaga1, Masakazu Nakano2, Mina Hoshino3
1Department of Gastroenterology, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi, 321-0293, Japan. tominaga@dokkyomed.ac.jp.
Clinical Journal of Gastroenterology
|July 17, 2015
Summary
Disasters impact gastrointestinal health across acute, subacute, and chronic phases. Key issues range from nutrition and hydration to conditions like peptic ulcers and inflammatory bowel disease.
Area of Science:
- Disaster medicine
- Gastroenterology
- Public health
Background:
- Large-scale disasters worldwide prompt medical investigations, including epidemiological studies.
- Gastrointestinal diseases are frequently identified in disaster-related health issues.
- These health problems manifest across acute, subacute, and chronic phases post-disaster.
Purpose of the Study:
- To review and synthesize the spectrum of gastrointestinal diseases and related health problems following large-scale disasters.
- To categorize gastrointestinal issues according to the temporal phases of disaster impact: acute, subacute, and chronic.
Main Methods:
- Review of existing medical literature, including epidemiological studies, case reports, and case series on disaster-related diseases.
- Analysis of identified gastrointestinal diseases based on their occurrence in different post-disaster phases.
Main Results:
- Acute phase issues primarily involve food security and nutrition.
- Subacute phase problems focus on constipation and diarrhea.
- Chronic phase concerns include upper gastrointestinal issues (peptic ulcer, functional dyspepsia) and lower gastrointestinal issues (inflammatory bowel disease, irritable bowel syndrome).
- Significant hepatobiliary pancreatic diseases like chronic hepatitis B and alcoholic liver disease/pancreatitis are also noted.
Conclusions:
- Gastrointestinal health is significantly affected by disasters, with distinct problems emerging in each phase.
- Understanding these phased impacts is crucial for effective disaster response and long-term health management.
- Targeted interventions are needed for nutritional support, managing bowel irregularities, and addressing chronic gastrointestinal and hepatobiliary conditions post-disaster.
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