Sinusoidal obstructive syndrome with hypereosinophilia successfully treated with prednisolone
Related Experiment Video
Updated: Apr 7, 2026
Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
Published on: April 25, 2025
Yuichi Yamaga1,2, Yukio Tsugihashi3, Takefumi Nakamura4
1Department of Gastroenterology and Hepatology, Kyoto University Graduate School, 54 Shogoin-kawahara cho, Sakyo-ku, Kyoto, 606-8507, Japan. yyamaga5@orion.ocn.ne.jp.
Abstract:
A 60-year-old man was admitted to Tenri Hospital complaining of erythema and abdominal distention. There were marked liver damage and hypereosinophilia. The patient was suffering from portal hypertension and coagulation disorder. We diagnosed the patient clinically as suffering from veno-occlusive disease, or sinusoidal obstructive syndrome (SOS). The pathological finding of the liver biopsy specimen was compatible with SOS. All of the manifestations, liver function test, and hemodynamics subsided shortly after administration of steroid treatment and ursodeoxycholic acid. The pathogenesis was not identified but some allergic reaction was suspected.
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