Assessing the Risks Associated with Antidepressant Use in Plastic Surgery: A Systematic Review
Isabel Teo1, Christopher Tam Song
1Dundee and Edinburgh, United Kingdom From Ninewells Hospital and the University of Edinburgh.
Plastic and Reconstructive Surgery
|July 17, 2015
Summary
Discontinuation of antidepressants before plastic surgery is not recommended due to low harm and potential withdrawal issues. However, understanding the reasons for antidepressant use is crucial for managing surgical risks.
Area of Science:
- Plastic Surgery
- Psychiatry
- Oncology
Background:
- Antidepressant use has significantly increased.
- Uncertainty exists regarding antidepressant use and plastic surgery outcomes.
- This review synthesizes available literature on antidepressant treatment risks in plastic surgery patients.
Purpose of the Study:
- To systematically review and evaluate the risks associated with antidepressant treatment in patients undergoing plastic surgery.
Main Methods:
- A comprehensive literature search of PubMed and Cochrane databases was performed.
- Articles were independently reviewed and data extracted by two reviewers.
- Inclusion criteria were used to select relevant studies for analysis.
Main Results:
- Twenty-six articles were analyzed, categorized by risks: bleeding, breast cancer, recurrence, breast enlargement, and miscellaneous complications.
- Low numbers needed to harm were observed for antidepressant cessation.
- No general increase in breast cancer risk or recurrence was found, except for concurrent tamoxifen and paroxetine use.
Conclusions:
- Cessation of antidepressants before plastic surgery is not supported due to low harm and potential withdrawal detriment.
- Understanding the indications for antidepressant prescription is vital for assessing surgical complication risks.
- While general breast cancer risks are not elevated, caution is advised for specific drug interactions (tamoxifen and paroxetine).
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