Related Experiment Video
Updated: Apr 7, 2026
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
Longitudinal Partial Volume Correction in 2-[18F]-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Studies of
Charles B Malpas1, Michael M Saling, Dennis Velakoulis
1From the *Melbourne Brain Centre, Royal Melbourne Hospital, Melbourne, Victoria, Australia; †Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia; ‡Department of Neuropsychology, Austin Health, Austin, Australia; §Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, Austin Hospital, Austin, Australia; ∥Melbourne Neuropsychiatry Centre, Royal Melbourne Hospital, Melbourne, Victoria, Australia; Departments of ¶Psychiatry and #Radiology, University of Melbourne, Melbourne, Victoria, Australia; Departments of **Radiology and ††Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia; and ‡‡The Sir Peter MacCallum Department of Oncology, the University of Melbourne, Melbourne, Victoria, Australia.
Objective:
To investigate partial volume correction (PVC) of 2-[F]-fluoro-2-deoxy-D-glucose positron emission tomography in Alzheimer disease in a longitudinal context.
Methods:
A total of 115 participants were included, including 55 controls, 53 patients with mild cognitive impairment, and 7 patients with dementia of the Alzheimer type. Imaging was performed at baseline and 24 months. Partial volume corrected vs uncorrected rates of longitudinal change were compared for mesial temporal and cortical regions of interest.
Results:
Partial volume correction increased apparent uptake, and this effect was greater at 24 months compared with baseline. Partial volume correction decreased the rate of decline, causing an apparent increase in uptake at 24 months compared with baseline. This effect was correlated with the structural atrophy.
Conclusions:
These findings suggest that applying PVC in a longitudinal context in Alzheimer disease might produce unpredictable results. Accordingly, both PVC corrected and uncorrected data should be reported to ensure that the results are physiologically plausible.
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