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RELATIONSHIP OF ADIPONECTIN LEVEL WITH LIPID PROFILE IN TYPE-2 DIABETIC MEN WITH CORONARY HEART DISEASE

Sadaf Durrani, Jasmin Shah, Mudassir Ahmad Khan

    Journal of Ayub Medical College, Abbottabad : JAMC
    |July 18, 2015
    PubMed

    Insights

    Serum adiponectin is significantly lower in type-2 diabetes patients with coronary heart disease (CHD). Low adiponectin correlates with poor lipid profiles, including high triglycerides and low HDL cholesterol, in these patients.

    Area of Science:

    • Endocrinology
    • Cardiology
    • Metabolic Diseases

    Background:

    • Type-2 diabetes mellitus is a leading cause of long-term cerebrovascular complications.
    • Coronary heart disease (CHD) is a significant concern in diabetic populations.
    • Understanding the role of adiponectin and lipid profiles in diabetic CHD is crucial.

    Purpose of the Study:

    • To determine serum adiponectin and lipid profile concentrations in type-2 diabetic men with CHD.
    • To investigate the relationship between adiponectin and lipid profiles in this cohort.
    • To compare these markers between diabetic patients with CHD and healthy individuals.

    Main Methods:

    • A cross-sectional study involving 36 healthy males and 36 type-2 diabetic males with CHD.
    • Analysis of fasting blood samples for serum adiponectin, glucose, HbA1c, and lipid profile (TC, TG, HDL-C, LDL-C).
    • Pearson correlation coefficient (r) used to assess relationships between variables.

    Main Results:

    • Diabetic men with CHD exhibited significantly lower serum adiponectin and HDL-C levels compared to healthy controls.
    • Elevated fasting blood glucose (FBG), HbA1c, total cholesterol (TC), triglycerides (TG), and LDL-C were observed in the diabetic CHD group.
    • Serum adiponectin showed a negative correlation with FBG, HbA1c, and TG, and a positive correlation with HDL-C in type-2 diabetic men with CHD.

    Conclusions:

    • Serum adiponectin concentration is markedly reduced in type-2 diabetes patients with coronary heart disease.
    • Hypoadiponectinemia is associated with dyslipidemia, characterized by high TG and low HDL-C, in this population.
    • Adiponectin levels are positively associated with HDL-C and negatively with HbA1c and TG.
    Abstract

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