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Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
Published on: March 17, 2019
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Mood instability underlies the relationship between impulsivity and internalizing psychopathology
Evyn M Peters1, Lloyd Balbuena1, Marilyn Baetz1
1Department of Psychiatry, University of Saskatchewan, 103 Hospital Drive, Saskatoon, SK S7N0W8, Canada.
Medical Hypotheses
|July 18, 2015
Summary
Impulsivity is linked to internalizing disorders, but this connection is explained by mood instability. Targeting mood instability may be more effective for treating these conditions.
Area of Science:
- Psychiatry
- Clinical Psychology
- Behavioral Science
Background:
- Impulsivity and mood instability are linked to internalizing disorders.
- The precise relationship between impulsivity, mood instability, and internalizing psychopathology requires further elucidation.
Purpose of the Study:
- To investigate the mediating role of mood instability in the association between impulsivity and internalizing psychopathology.
- To examine this relationship in both cross-sectional and longitudinal data.
Main Methods:
- Two studies utilized existing datasets (Adult Psychiatric Morbidity Survey, British Health and Lifestyle Surveys).
- Sequential regression analyses were employed to test the hypothesized mediation.
- Measures included the Structured Clinical Interview for DSM-IV Axis-II Personality Disorders, revised Clinical Interview Schedule, Eysenck Personality Inventory, and General Health Questionnaire.
Main Results:
- In Study 1, the link between depression and impulsivity was non-significant when mood instability was accounted for.
- In Study 2, impulsivity's predictive effect on future internalizing symptoms became non-significant after including mood instability.
- Mood instability significantly mediated the relationship between impulsivity and internalizing psychopathology in both studies.
Conclusions:
- The association between impulsivity and internalizing psychopathology is largely explained by mood instability.
- Clinical interventions for internalizing conditions may benefit from focusing on mood instability rather than impulsivity directly.
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