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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.2K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.2K

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Related Experiment Video

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Isolation, Transfection, and Long-Term Culture of Adult Mouse and Rat Cardiomyocytes
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Non-Coding RNAs in Cardiac Aging.

Hui Wang, Yihua Bei, Jing Shi

    Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
    |July 18, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Cardiac aging impairs heart function and increases cardiovascular disease risk. Non-coding RNAs, including microRNAs and long non-coding RNAs (lncRNAs), dynamically regulate this aging process.

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    Area of Science:

    • Cardiology
    • Molecular Biology
    • Gerontology

    Background:

    • Aging significantly impacts cardiac function, increasing cardiovascular disease risk.
    • Cardiac aging involves intrinsic physiological processes, cellular, and molecular alterations.
    • Non-coding RNAs (ncRNAs) are crucial regulators in biological processes.

    Purpose of the Study:

    • To review the role of non-coding RNAs in cardiac aging.
    • To explore the mechanisms by which ncRNAs influence cardiac homeostasis and aging.
    • To provide an overview of microRNAs and long non-coding RNAs (lncRNAs) in cardiac aging.

    Main Methods:

    • Literature review of studies on non-coding RNAs and cardiac aging.
    • Analysis of molecular and cellular mechanisms.
    • Synthesis of current evidence on ncRNA function in the aging heart.

    Main Results:

    • Non-coding RNAs, including microRNAs and lncRNAs, are key modifiers of cardiac aging.
    • These molecules play dynamic roles in maintaining cardiac homeostasis.
    • Dysregulation of ncRNAs contributes to age-related cardiac dysfunction.

    Conclusions:

    • Non-coding RNAs are critical regulators of cardiac aging.
    • Targeting ncRNAs may offer therapeutic strategies for age-related heart disease.
    • Further research into ncRNA mechanisms can elucidate pathways for cardiac health maintenance.