Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conserved Binding Sites01:49

Conserved Binding Sites

5.3K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemical composition and insecticidal activity of Salvia rosmarinus 'Eretto Liguria' essential oil against tomato leaf miner (Tuta absoluta).

Scientific reports·2026
Same author

Integrating Metabolomics and Digital Tools to Valorise Aromatic Ecotypes in Sustainable Agriculture.

Studies in health technology and informatics·2026
Same author

Plant Defense Unveiled: From Classical Experiments to Bioinformatics-Driven Genomics.

Studies in health technology and informatics·2026
Same author

The challenges of national health data ecosystems in feeding the European health data space: the Italian example.

Frontiers in medicine·2025
Same author

Sustainable Agrochemical Exploitation of Ligurian Aromatic Plant Ecotypes.

Studies in health technology and informatics·2024
Same author

NMR Metabolite Profiling for the Characterization of Vessalico Garlic Ecotype and Bioactivity against <i>Xanthomonas campestris</i> pv. <i>campestris</i>.

Plants (Basel, Switzerland)·2024

Related Experiment Video

Updated: Apr 6, 2026

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

9.9K

Prediction of potential barcoding sites on ITS1 by wavelet transform.

Norbert Maggi1, Carmelina Ruggiero1, Patrizio Arrigo2

  • 1a DIBRIS - University of Genoa , Genoa , Italy.

Journal of Biomolecular Structure & Dynamics
|July 18, 2015
PubMed
Summary

This study introduces a novel method for selecting optimal molecular probes, enhancing specificity in DNA barcoding. The approach integrates wavelet transforms and biological data to improve biodiversity conservation and biotechnology applications.

Keywords:
DNA barcodingbioinformaticsdigital signal processing

More Related Videos

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

12.6K
Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples
08:18

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

Published on: April 7, 2023

2.3K

Related Experiment Videos

Last Updated: Apr 6, 2026

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

9.9K
Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

12.6K
Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples
08:18

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

Published on: April 7, 2023

2.3K

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Bioinformatics

Background:

  • Sustainable development requires integrating biodiversity conservation and quality of life improvements.
  • Molecular techniques enhance the investigation of subtle biological differences and environmental impacts.
  • Optimal selection of molecular probes is crucial for various biotechnological applications.

Purpose of the Study:

  • To propose an approach for optimal molecular probe selection in barcoding applications.
  • To maximize probe specificity by integrating computational and biological data.
  • To develop tools for improved biodiversity assessment and molecular screening.

Main Methods:

  • Integrated a wavelet transform-based filter system with biological sequence data.
  • Incorporated knowledge of sequence mutation and post-translational modification proneness.
  • Tested the method on Internal Transcribed Spacer 1 (ITS1) sequences from the rRNA locus.

Main Results:

  • Identified local relative stable conformations in ITS1 sequences beyond known cleavage sites.
  • Observed distinct characteristics of these conformations across different mammalian species.
  • Demonstrated the potential for designing species-specific barcoding probes.

Conclusions:

  • The proposed method effectively enhances molecular probe specificity.
  • Identified sequence variations can be leveraged for novel molecular screening tools.
  • This approach supports biodiversity conservation and advancements in biotechnology.