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Frequency of Left Ventricular Hypertrophy in Non-Valvular Atrial Fibrillation

Marco Proietti1, Alberto Maria Marra2, Eliezer Joseph Tassone3

  • 1University of Birmingham, Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom; I Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza-University of Rome, Rome, Italy.

The American Journal of Cardiology
|July 18, 2015
PubMed

Insights

Left ventricular hypertrophy (LVH) affects over half of patients with non-valvular atrial fibrillation (AF). Key factors include female gender, older age, hypertension, diabetes, and prior myocardial infarction, indicating high cardiovascular risk.

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Medical Research

Background:

  • Left ventricular hypertrophy (LVH) is a significant predictor of adverse cardiovascular events.
  • Prevalence and determinants of LVH in patients with atrial fibrillation (AF) are inconsistently reported due to varied definitions and population heterogeneity.
  • Non-valvular AF (NVAF) patients represent a population at high risk for cardiovascular complications.

Purpose of the Study:

  • To determine the prevalence of echocardiographic-based LVH in a prospective cohort of patients with NVAF.
  • To identify clinical factors independently associated with the development of LVH in this population.

Main Methods:

  • Analysis of 1,184 patients from the ARAPACIS registry with NVAF and complete data for LVH assessment.
  • Prospective, observational, multicenter study design.
  • Logistic regression analysis to identify independent predictors of LVH.

Main Results:

  • A high prevalence of LVH (52%) was observed in patients with NVAF.
  • Patients with LVH were older and had higher rates of hypertension, diabetes, and previous myocardial infarction (MI).
  • LVH was associated with increased thromboembolic risk (CHA2DS2-VASc ≥2 in 93% of LVH patients) and female gender, older age, hypertension, diabetes, and prior MI were independent predictors.

Conclusions:

  • Non-valvular AF patients exhibit a high prevalence of LVH.
  • Female gender, older age, hypertension, diabetes, and prior MI are independently associated with LVH in NVAF.
  • These findings underscore the high thromboembolic risk in NVAF patients with LVH, necessitating comprehensive cardiovascular prevention strategies.

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