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Vascular remodeling of the circle of Willis in moyamoya disease

Takeshi Mikami, Shouhei Noshiro, Katsuya Komatsu

    Neurological Research
    |July 18, 2015
    PubMed
    Abstract

    Insights

    Moyamoya disease patients exhibit reduced outer vessel diameters in the circle of Willis, particularly the middle cerebral artery (MCA), indicating a constrictive remodelling pattern. This finding aids in understanding disease progression.

    Area of Science:

    • Neuroimaging
    • Vascular Neurology
    • Radiology

    Background:

    • Atherosclerotic disease shows positive (outward) vascular remodelling.
    • Moyamoya disease is a cerebrovascular disorder characterized by progressive stenosis of intracranial arteries.

    Purpose of the Study:

    • To evaluate the outer diameter of the circle of Willis in moyamoya disease patients using MRI.
    • To verify the remodelling pattern in these vessels.

    Main Methods:

    • 18 moyamoya disease patients underwent fast imaging employing steady-state acquisition (FIESTA) MRI.
    • Outer diameters of internal carotid artery (C1), middle cerebral artery (M1), and anterior cerebral artery (A1) were measured.
    • Comparison with a control group and correlation with magnetic resonance angiography (MRA) scores were performed.

    Main Results:

    • Moyamoya patients had significantly smaller C1, M1, and A1 diameters compared to controls (P < 0.0001).
    • M1 diameter strongly correlated with moyamoya disease MRA scores (R=0.72).
    • C1 diameter showed only a weak correlation with MRA scores (R=0.21).

    Conclusions:

    • Patients with moyamoya disease generally have reduced outer vessel diameters around the C1.
    • The middle cerebral artery (MCA) diameter reduction progresses with the disease, suggesting a negative (constrictive) remodelling pattern.
    Keywords:
    Intima thickening,Magnetic resonance imaging,Moyamoya disease,Remodeling pattern

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