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Related Concept Videos

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

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Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
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Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
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Diffuse Interface Methods for Modeling Drug-Eluting Stent Coatings.

David M Saylor1, Christopher Forrey2, Chang-Soo Kim3

  • 1Food and Drug Administration, Silver Spring, MD, 20993, USA. david.saylor@fda.hhs.gov.

Annals of Biomedical Engineering
|July 18, 2015
PubMed
Summary
This summary is machine-generated.

Diffuse interface models offer a powerful approach to understanding drug-eluting stent coatings. These models incorporate microscale heterogeneities to predict drug release and guide product development.

Keywords:
Controlled releaseDiffusionMicrostructureSimulationThermodynamics

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Area of Science:

  • Biomaterials Science
  • Chemical Engineering
  • Computational Modeling

Background:

  • Drug-eluting stent coatings are critical for localized drug delivery.
  • Coating performance is significantly influenced by microscale heterogeneities.
  • Existing models often simplify or ignore these crucial microstructural details.

Purpose of the Study:

  • To present an overview of diffuse interface models for drug-eluting stent coatings.
  • To demonstrate how these models can incorporate microscale heterogeneities.
  • To highlight the predictive capabilities of diffuse interface models for coating behavior and drug release.

Main Methods:

  • Application of diffuse interface methods to model coating microstructures.
  • Incorporation of heterogeneities in coating and use environment into model equations.
  • Simulation of phenomena such as crystallization, phase separation, degradation, and binding.

Main Results:

  • Diffuse interface models can explicitly include microscale heterogeneities.
  • Models enable prediction of microstructural evolution during fabrication.
  • These models can forecast the impact of microstructures on drug release kinetics.
  • Demonstrated applicability to diverse phenomena like crystallization and degradation.

Conclusions:

  • Diffuse interface models provide a robust framework for analyzing drug-eluting stent coatings.
  • These models can predict complex phenomena influencing coating performance.
  • Challenges remain in material data acquisition and numerical solutions.
  • The models show significant potential for guiding product and process development.