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Published on: June 23, 2020
Duration of prior vancomycin therapy and subsequent daptomycin treatment outcomes in methicillin-resistant
Darren Culshaw1, Kenneth C Lamp1, Min J Yoon1
1Merck and Co., Kenilworth, NJ, USA.
Abstract:
The association between varying durations of previous vancomycin therapy and subsequent daptomycin success rates was evaluated in a subset of patients with methicillin-resistant Staphylococcus aureus bacteremia from the Cubicin® Outcomes Registry and Experience 2005-2009 (n=159). Previous vancomycin exposure did not adversely affect daptomycin outcomes; success rates were 81% in patients treated with first-line daptomycin and 89%, 83%, and 88%, respectively, in patients with 1-3days, 4-6days, and ≥7days of previous vancomycin exposure (P=0.5).
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