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Published on: May 4, 2021
Relation between ADIPOQ Gene Polymorphisms and Type 2 Diabetes
Zhi-Peng Li1, Mei Zhang2, Jie Gao3
1Golden Card Hospital, West China Hospital, Sichuan University, Chengdu 610041, China. zhilipengirl@126.com.
Objective:
The manuscript investigates the relation between adiponectin gene (ADIPOQ) polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population.
Methods:
We designed a case-control study involving 340 normal glucose tolerant (NGT) subjects and 340 type 2 diabetes patients. Three SNPs (rs182052, rs1501299, and rs7627128) were genotyped by TaqMan methods.
Results:
We found that rs7627128, rs1501299 and rs182052 were significantly associated with T2DM. Haplotypes analysis indicated that the frequency of the haplotypes A-A-T was frequent in T2DM patients (OR = 2.10; 95%CI: 1.44-2.90; p < 0.001), but G-A-T was more frequent in the control group than in the T2DM group (OR = 0.66; 95%CI: 0.54-0.81; p < 0.001).
Conclusion:
The ADIPOQ genetic polymorphisms were associated with type 2 diabetes in a Chinese population.
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